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Educational summary · not yet reviewed by a medical professional

EARLYSupplement or cosmetic·Not on the WADA list

Matrixyl

Also called Palmitoyl pentapeptide-4, Palmitoyl tripeptide-1

Matrixyl is a family of signal peptides used in anti-aging skincare. Small studies suggest it can improve the look of fine lines.

What it is

Peptides attached to a fatty acid so they can penetrate the skin's surface.

What the evidence shows

In people

Small, often manufacturer-funded studies report improvements in the appearance of wrinkles.

In animals and labs

Lab studies on collagen signaling in skin cells.

Legal status

Legal as a cosmetic ingredient.

Dosing

Follow the product label

Supplements and skincare products are used as directed on their label. Choose products with third-party testing, and check with a clinician if you are pregnant, nursing, or take medication.

Known risks

  • Mild irritation in sensitive skin

Sources

Last updated 2026-11-03

Educational only and not medical advice. Talk to a licensed clinician before starting any peptide. Medical disclaimer.