Sermorelin
Sermorelin is a short version of growth-hormone-releasing hormone. It was once FDA-approved, but the branded product was discontinued, and there is no approved product on the market today.
What it is
The first 29 amino acids of natural GHRH, which prompts the pituitary to release growth hormone.
What the evidence shows
In people
Older clinical studies in children with growth hormone deficiency supported its original approval. Evidence for anti-aging or body composition use in adults is weak.
In animals and labs
Mechanism is well characterized.
Legal status
Previously approved as Geref and later withdrawn from the market. It is prohibited in sport.
Dosing
There is no established human dose
No regulator has approved a dose for human use. Numbers shared online come from animal studies, small early trials, or seller protocols, and none of them have been shown to be safe or effective. BOTH does not publish dosing, mixing, or injection instructions for unapproved compounds.
Known risks
- Injection-site reactions, flushing, and headache
- Unknown benefit for healthy adults
- Quality varies across sources