MOTS-c
MOTS-c is a peptide made by mitochondria that has been studied in animals for metabolism and exercise capacity. There is almost no human trial data, and it is not approved.
What it is
A small peptide encoded in mitochondrial DNA that may help regulate how cells use energy.
What the evidence shows
In people
Mostly observational measurements of natural MOTS-c levels. No meaningful trials of taking it.
In animals and labs
Mouse studies report effects on insulin sensitivity and exercise capacity.
Legal status
Not FDA-approved.
Dosing
There is no established human dose
No regulator has approved a dose for human use. Numbers shared online come from animal studies, small early trials, or seller protocols, and none of them have been shown to be safe or effective. BOTH does not publish dosing, mixing, or injection instructions for unapproved compounds.
Known risks
- Unknown human safety
- Quality and identity vary across research suppliers